Human brain cortex in a dish! VIA Science Mission

Researchers have devised a way to generate spherical, free-floating balls of human brain cells that mimic the architecture of the cerebral cortex, the outer layer of brain tissue responsible for how we experience and perceive the world around us and how we interact with others.

The spheres contain functional neurons, working synapses and even critical support cells called astrocytes that maintain neural function. They also express genes in patterns similar to a human fetal brain midway through pregnancy.

These “human cortical spheroids” developed (published in Nature Methods) using a single human skin sample can grow to be as large as 5 millimeters in diameter and can be maintained in the laboratory for nine months or more. They exhibit complex neural network activity and can be studied with techniques well-honed in animal models.

The researchers hope that tracking the development of the cortex-like spheroids over time and observing the interactions of their cells may shed light on human brain development and the molecular causes of neuropsychiatric disorders such as autism and schizophrenia.

http://med.stanford.edu/…/tiny-spheres-of-human-cells-mimic…

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